Gastrointestinal drugs support the digestive system by reducing stomach acid, improving gut motility, and relieving symptoms such as heartburn, ulcers, or constipation. These medications are commonly used for GERD, IBS, peptic ulcers, and other digestive conditions.
| Drug Name | Class / Description |
|---|---|
| Omeprazole | PPI – reduces stomach acid for GERD and ulcers |
| Esomeprazole | PPI – treats acid reflux and heartburn |
| Lansoprazole | PPI – prevents and heals peptic ulcers |
| Pantoprazole | PPI – used for GERD and Zollinger-Ellison syndrome |
| Rabeprazole | PPI – decreases stomach acid and heals ulcers |
| Famotidine | H2 blocker – reduces acid production and treats heartburn |
| Ranitidine | H2 blocker – formerly used for acid reflux (largely withdrawn) |
| Nizatidine | H2 blocker – treats ulcers and acid reflux |
| Sucralfate | Protective agent – coats stomach lining to heal ulcers |
| Misoprostol | Prostaglandin analog – protects stomach from NSAID damage |
| Metoclopramide | Prokinetic – promotes gastric emptying and reduces nausea |
| Domperidone | Prokinetic – improves stomach motility and reduces bloating |
| Ondansetron | Antiemetic – blocks nausea and vomiting |
| Prochlorperazine | Antiemetic – used for nausea, vomiting, and vertigo |
| Meclizine | Antihistamine – treats motion sickness and dizziness |
| Dimenhydrinate | Antiemetic – prevents motion sickness |
| Bismuth subsalicylate | Antidiarrheal – relieves upset stomach and diarrhea |
| Loperamide | Antidiarrheal – slows bowel movements for diarrhea relief |
| Diphenoxylate | Antidiarrheal – opioid derivative used with atropine |
| Atropine | Antispasmodic – relieves abdominal cramps and GI spasms |
| Hyoscyamine | Anticholinergic – reduces stomach acid and intestinal cramps |
| Dicyclomine | Antispasmodic – relieves IBS-related cramping |
| Simethicone | Antiflatulent – reduces bloating and gas discomfort |
| Lactulose | Laxative – treats constipation and liver-related toxin buildup |
| Polyethylene glycol | Osmotic laxative – softens stool and promotes bowel movements |
| Senna | Stimulant laxative – increases intestinal activity |
| Bisacodyl | Stimulant laxative – used for constipation relief |
| Magnesium hydroxide | Laxative / Antacid – neutralizes acid and relieves constipation |
| Calcium carbonate | Antacid – relieves heartburn and indigestion |
| Aluminum hydroxide | Antacid – neutralizes stomach acid |
| Magnesium trisilicate | Antacid – provides acid neutralization and comfort |
| Pantoprazole | PPI – used for GERD, ulcers, and acid control |
| Cisapride | Prokinetic – enhances gastric motility (restricted use) |
| Lubiprostone | Chloride channel activator – used for chronic constipation |
| Linaclotide | Guanylate cyclase-C agonist – treats IBS-C and chronic constipation |
| Plecanatide | GC-C agonist – relieves constipation and IBS symptoms |
| Mesalamine | Anti-inflammatory – used for ulcerative colitis and Crohn’s disease |
| Sulfasalazine | Anti-inflammatory – reduces inflammation in IBD |
| Azathioprine | Immunosuppressant – used in severe Crohn’s disease and ulcerative colitis |
| Infliximab | Biologic – treats moderate to severe IBD |
| Adalimumab | Biologic – TNF inhibitor for Crohn’s disease and ulcerative colitis |